https://jdcr.sciforce.org/JDCR <p>Navigating the Frontier of Drug Delivery: Journal of Drug Delivery and Controlled Release (JDCR) by Sciforce Publications</p> <p>Step into the realm of cutting-edge drug delivery and controlled release science with the Journal of Drug Delivery and Controlled Release (JDCR), a distinguished publication by Sciforce Publications. JDCR is your gateway to the latest research and developments in the fields of drug delivery systems, pharmaceutical formulations, and controlled release technologies. In this web content, we'll delve into the significance of JDCR, its contributions to the scientific community, and the dynamic world of drug delivery and controlled release.</p> <p> </p> www.sciforce.org en-US International Journal of Drug Delivery & Controlled Release 2770-7814 https://jdcr.sciforce.org/JDCR/article/view/233 <p>Presently, acne is affecting globally many people (9.4%) and one of the leading causes of stress especially in youths. Adapalene (AD) has been applied successfully for acne treatment. However, adapalene drug is from BCS class II and exhibits less solubility in water (&lt;1mg/mL) &amp; causes skin irritation which leads to patient incompliance. The objective of the current study was design of microemulsion-based gel for topical delivery of adapalene. Solubility studies demonstrated that adapalene exhibit good solubility in Tween 80, propylene glycol, and oleic acid. The microemulsion showed globule size 248.4±2 nm, PDI (0.251), and Zeta potential (-15.8 mV) confirming colloidal stability. The dilutability and freeze-thaw study of microemulsion showed no sign of phase separation. The microemulsion-based gel showed clarity, pH (5±0.5), viscosity (64cps), and good spreadability (6.5±0.6 cm) for topical application. In-vitro gel formation study showed that inclusion of polymer (Carbopol 940) maintained viscosity of microemulsion-based hydrogel for longer period of time. Dissolution study demonstrated that AD showed sustained release for 24h from gel as compared to microemulsion and drug suspension. &nbsp;Thus, it could be a prospective formulation for acne treatment via topical route which can improve patient compliance by reducing skin irritation.</p> Dr. Shilpa Dawre Copyright (c) 2023 International Journal of Drug Delivery & Controlled Release 2023-06-06 2023-06-06 2 1 38 44 10.55124/jdcr.v2i1.233